Ryun yu biography of abraham

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I obtained my Ph.D. from the University of British Columbia under the supervision of Professor Marcel Bally, developing lipid membrane nanoparticle delivery systems which founded my interest in cancer therapeutics, lipid bilayer chemistry and nano-based structures. My Ph.D. thesis and first 1st authored publication served as the basis of my inventorship toward the development of the FDA approved (2017) liposomal formulation VyxeosTM. Completed clinical trials demonstrate that VyxeosTM treatment doubles the overall median survival rate and reduces the risk of death by 31% for patients with acute myeloid leukaemia (AML). AML, the most common of all adult leukaemias, has the poorest survival rates with pharmacological treatment remaining unchanged for 30 years. After my Ph.D., I carried out a doctoral fellowship in cellular biology supported by the Natural Science and Engineering Research Council (NSERC) with Professor Paul Lehner at the University of Cambridge studying RING ubiquitin E3 ligases that regulate immune receptors. I completed a second post doctorate with Professor Tessa Holyoake, funded by Bloodwise that involved investigating critical pathways in chronic myeloid leukaemia (CML). This study was the first comparative proteomic screen of normal vs CML stem cells with the identification of a therapeutic regimen based on in silico analyses. Our strategy targeting multi-connected nodes based on network analyses proved superior to treatment with the most successful rationally-designed drug of the last century: Imatinib.

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Our research involves interrogating signalling events critical to the development and maintenance of both normal haematopoietic and cancer stem cells. To accomplish this, our research integrates biochemical and molecular biological techniques, primary human tissue culturing techniques, nanoparticle characterization and sizing, chromatography, mass spectrometry (MS), RN

Abraham Feder began his tenure with the Detroit Symphony Orchestra as Assistant Principal Cello in the fall of 2018. Prior to his appointment, he was a member of the Dallas Symphony Orchestra. During the summer of 2018, he served as Assistant Principal Cello of the Santa Fe Opera. Feder began his orchestral career as Principal Cello of the Sarasota Orchestra and as cellist of the Sarasota String Quartet from 2008–2016.

Feder has been featured as a soloist with the Sarasota Orchestra, the Duluth Superior Symphony Orchestra, the Orchestra of the Americas, and the Chicago Youth Symphony Orchestra. In 2013, as a member of the Chroma Quartet, he founded the Tuesdays with Chroma concert series in Sarasota.

An avid chamber musician, Feder has performed with Ricardo Morales, Amy Oshiro Morales, and Kerri Ryan of the Philadelphia Orchestra; Michelle Kim, Assistant Concertmaster of the New York Philharmonic; Richard Hirschl, Brant Taylor, Kenneth Olson, and Yuan-Qing Yu of the Chicago Symphony Orchestra (CSO); Stephen Balderston, former Assistant Principal Cello of the CSO; Desomd Hoebig, former Principal Cello of the Cleveland Orchestra; Danielle Belen; Joseph Silverstein; Ray Chen; Christopher O’Riley; and Leonidas Kavakos.

Feder earned his master’s degree under the tutelage of Desmond Hoebig at Rice University's Shepherd School of Music. He received a Bachelor of Music at The Curtis Institute of Music where he studied with David Soyer and Peter Wiley. His teachers have also included Richard Hirschl and Tanya Carey.